Calculating mitochondrial half life

Method:

Data from "The Turnover of Mitochondria in a variety of tissues of young adult and aged rats", Menzies & Gold, JBC 1971. Used combined aged & young adult data.

http://www.jbc.org/content/246/8/2425.full.pdf

Report data for mean half-life from decay constant +- 95% confidence interval (CI)

Calculated s.d. using s.d. = sqrt(n)*C/1.96 where C is 95% CI value

Input data into Caladis using t = ln(2)*(1/k) for decay constant k with mean reported and s.d. calculated as above.

Other tissue types available (not calculated): intestinal mucus, lung, kidney

Results:

Rat liver: www.caladis.org/compute/?q=0.693147181*(1%2F%24k)&v=k%3Anorm%2C0.077%2C0.01420348051&x=off&n=m&h=fd&a=rad&_=1430136704460

Rat testes: www.caladis.org/compute/?q=0.693147181*(1%2F%24k)&v=k%3Anorm%2C0.0551%2C0.01704417662&x=off&n=l&h=fd&a=rad&_=1430137357231

Rat heart: www.caladis.org/compute/?q=0.693147181*(1%2F%24k)&v=k%3Anorm%2C0.0396%2C0.01136278441&x=off&n=l&h=fd&a=rad&_=1430138273017

Rat brain: http://www.caladis.org/compute/?q=0.693147181*(1%2F%24k)&v=k%3Anorm%2C0.0283%2C0.01420348051&x=off&n=l&h=fd&a=rad